P-105: Genetic Variation of Kinase Insert Domain-Containing Receptor Gene and Its Association with Recurrent Spontaneous Abortion

Background Recurrent spontaneous abortion has been defined two or more consecutive miscarriages at 20 weeks pregnancy and one of diseases that can lead to physical, psychological and economical for the individual problems. Recently number of polymorphisms in several genes was examined for association analyses in pregnant women which related to endanger the life of the fetus. In present study we investigated allele frequency of SNP in Kinase insert Domain Receptor (KDR) gene in women with recurrent miscarriage. MaterialsAndMethods One hundred women with recurrent spontaneous abortion of the fetus with at least 2 or more miscarriages before 20 weeks and without anatomical problems of the uterus, cytogenetic, hormonal problems as patients and 100 women with no history of abortion and with having had successful birth were chosen as controls. For polymorphism analysis of functional SNP rs1870377, PCR-RFLP was performed by using the restriction enzymes AluI and digested products were visualized on 12% acrylamide gel respectively. The differences between allele frequency in two grouped were calculated by chi square test with P value